Tumors, Fighting, and Babies: See All the Drama Coming Up on Season 5 of The Kardashians

It's Kiki vs. Koko in The Kardashians season five.

After spending the last few seasons embroiled in a feud with Kourtney Kardashian, Kim Kardashian is now at odds with Khloe Kardashian as seen in the latest trailer for the Hulu series, which dropped May 8.

First, in a confessional, the SKIMS founder says that "Khloe is unbearable these days," also telling mom Kris Jenner that Khloe is "very judgmental." Then during a chat between the two, Kim tells Khloe, "You don't realize you sometimes have a stick up your a–."

The Good American founder doesn't take this jab lightly as she retorts, "You are going through a lot right now and you're taking it out on me." Cut away to Kim exclaiming, "Get out!"

Family isn't always easy, as Khloe declares in a confessional: "Sisters can be vicious and brutal."

That's not the only eyebrow raising moment fans can expect to see this season, which premieres May 23. In the teaser, Kourtney details her health challenges, including undergoing emergency surgery while pregnant with her and Travis Barker's son Rocky Thirteen, now 6 months. 

photosKim Kardashian's Most Challenging Met Gala Looks

And Kris shares a concerning medical diagnosis with her loved ones.

"I had my scan," the momager is heard saying. "They found a cyst and a little tumor."

Then there's Khloe's love life. Though she co-parents daughter True Thompson, 6, and son Tatum Thompson, 21 months, with ex Tristan Thompson, Kourtney wants her sister to live a little.

"Now that Tristan is gone, maybe Khloe could be free to go out and have fun," Kourtney is heard saying, and asks her sister directly, "Are you having sex?"

But Khloe just wants them to back off. As she declares in a confessional, "I don't care what other people think. I'm happy."

Look back at the love lives of the Kardashians stars…